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朱灵
单位:安徽光机所
地址:安徽省合肥市蜀山湖路350号
邮编:230031
电话:0551-65592128
个人主页: http://tutor.hfcas.ac.cn/tutor/tutor-info?id=45
 
个人简历 Personal resume
朱灵,博士,研究员,中国科学院合肥物质科学研究院安徽光机所光电子中心副主任,中国科学院青年创新促进会优秀会员,入选安徽省高层次人才。现任安徽省生物医学光学仪器工程技术研究中心副主任、安徽省医用光学诊疗技术与装备工程研究中心副主任,兼任中国光学学会生物医学光子学专委会委员、中国研究型医院学会生物标志物专委会委员等学术职务,担任国家、中国科学院、安徽省相关领域专家组成员。

长期聚焦微纳生物传感与先进分子诊断装备研发,主持国家重点研发计划、国家自然科学基金、中科院先导专项、中科院重点部署、安徽省科技重大专项等重大任务,带领团队构建了“核心元件—关键工艺—系统集成—场景应用”全链条技术体系。在集成化微流控芯片、数字PCR、CRISPR/Cas免扩增检测及巢式固相多重荧光PCR等方向取得系列突破,成果发表于Biosensors and Bioelectronics、Analytical Chemistry等权威期刊。主导研制多款微流控芯片及配套核酸检测设备,获二类医疗器械注册证3项,申请发明专利30余项。原创“电荷吸附”核酸富集技术已在公安系统实战应用,研制的虫媒传染病一体化微流控POCT系统通过国家卫健委验收并在海关口岸应用示范。已发表论文100余篇,获省院共建突出贡献奖一等奖等奖励。

 
研究方向 Research direction
团队主要从事光学与生物医学交叉领域的研究工作,聚焦微纳生物光子传感技术,致力于发展面向生物医学检测及疾病诊断的高灵敏度、高通量光学检测新方法。研究方向涵盖:

(1)基于新一代CRISPR技术的核酸免扩增快速检测;

(2)数字微流控单分子绝对定量检测技术;

(3)免疫细胞迁移行为的微流控芯片系统及其动态分析。

特色与优势:

以DNA等生物标志物为核心研究对象,融合微纳流控芯片与先进光学检测手段,开发全自动化一体化检测系统,实现从样品到结果的封闭式、全流程分子诊断,并推进单分子水平的绝对定量分析。

人才培养:

课题组注重学生学术视野与工程实践能力的综合培养,近年来指导的研究生多次获得国家奖学金、悦群特等奖学金、江淮蔚来专项奖学金、东超奖学金等奖励,多名学生获评优秀毕业生及中央选调生等荣誉。
 
招生信息 Enrollment information
学术博士:生物物理学 
工程博士:电子信息、生物医药

欢迎生物医学工程、生物技术、生物科学、生物物理学、仪器科学与技术、自动化、电子信息、机械等相关专业的本科生和硕士生报考,课题组将提供良好的科研平台及多学科交叉研究条件
 
论文专著 The monograph
1) Mobile lab: A novel pathogen assay using the nucleic acid automatic assay system assisted by a self-contained microfluidic cassette and chitosan decorating magnetic particles - Sensors and Actuators B: Chemical - 2024
2) CRISPR/Cas and Argonaute-based biosensors for nucleic acid detection - Talanta - 2025
3) An Integrated Microfluidic Platform for Label-Free Sorting and Functional Assessment of Neutrophils in Sepsis - Analytical Chemistry - 2025
4) Lift-CM: An integrated lift-heater centrifugal microfluidic platform for point-of-care pathogen nucleic acid detection using isothermal amplification and CRISPR/Cas12a - Sensors and Actuators B: Chemical - 2025
5) A Planar Darkfield Illuminator for Wide-Field High-Contrast Imaging of Specimens in Microfluidic Chips - Laser & Photonics Reviews - 2024
6) Mobile lab: A novel pathogen assay using the nucleic acid automatic assay system assisted by a self-contained microfluidic cassette and chitosan decorating magnetic particles - Sensors and Actuators B: Chemical - 2024
7) SEDphone: Spatial encoding of centrifugal microfluidic disc integrated smartphone-controlled platform via RT/LAMP-CRISPR/Cas12a system for influenza virus subtypes detection - Sensors and Actuators B: Chemical - 2024
8) An Integrated Microfluidic Platform for Label-Free Sorting and Functional Assessment of Neutrophils in Sepsis - Analytical Chemistry - 2025
9) Lift-CM: An integrated lift-heater centrifugal microfluidic platform for point-of-care pathogen nucleic acid detection using isothermal amplification and CRISPR/Cas12a - Sensors and Actuators B: Chemical - 2025
10) CRISPR/Cas and Argonaute-based biosensors for nucleic acid detection - Talanta - 2025
11) SEDphone: Spatial encoding of centrifugal microfluidic disc integrated smartphone-controlled platform via RT/LAMP-CRISPR/Cas12a system for influenza virus subtypes detection - Sensors and Actuators B: Chemical - 2024
12) SEDphone: Spatial encoding of centrifugal microfluidic disc integrated smartphone-controlled platform via RT/LAMP-CRISPR/Cas12a system for influenza virus subtypes detection - Sensors and Actuators B: Chemical - 2024
13) A Planar Darkfield Illuminator for Wide-Field High-Contrast Imaging of Specimens in Microfluidic Chips - Laser & Photonics Reviews - 2024
14) A Planar Darkfield Illuminator for Wide-Field High-Contrast Imaging of Specimens in Microfluidic Chips - Laser & Photonics Reviews - 2024
15) Mobile lab: A novel pathogen assay using the nucleic acid automatic assay system assisted by a self-contained microfluidic cassette and chitosan decorating magnetic particles - Sensors and Actuators B: Chemical - 2024
16) SEDphone: Spatial encoding of centrifugal microfluidic disc integrated smartphone-controlled platform via RT/LAMP-CRISPR/Cas12a system for influenza virus subtypes detection - Sensors and Actuators B: Chemical - 2024
17) A Planar Darkfield Illuminator for Wide-Field High-Contrast Imaging of Specimens in Microfluidic Chips - Laser & Photonics Reviews - 2024
18) Mobile lab: A novel pathogen assay using the nucleic acid automatic assay system assisted by a self-contained microfluidic cassette and chitosan decorating magnetic particles - Sensors and Actuators B: Chemical - 2024
19) SEDphone: Spatial encoding of centrifugal microfluidic disc integrated smartphone-controlled platform via RT/LAMP-CRISPR/Cas12a system for influenza virus subtypes detection - Sensors and Actuators B: Chemical - 2024
20) A Planar Darkfield Illuminator for Wide-Field High-Contrast Imaging of Specimens in Microfluidic Chips - Laser & Photonics Reviews - 2024
21) Mobile lab: A novel pathogen assay using the nucleic acid automatic assay system assisted by a self-contained microfluidic cassette and chitosan decorating magnetic particles - Sensors and Actuators B: Chemical - 2024
 
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