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王宏达
单位：长春应用化学研究所
地址：吉林省长春市人民大街5625号
邮编：130022
电话：86-431-85262453
个人主页： http://yjsb.ciac.cas.cn/dsjj/fxhx/201905/t20190507_486656.html
 
个人简历 Personal resume 
王宏达，中国科学院长春应用化学研究所研究员，中国科学院“国家杰出青年基金”、“科技部中青年科技创新领军人才”获得者。1995年毕业于吉林大学分子生物学系获学士学位，2000年毕业于中科院长春应用化学研究所获分析化学博士学位，2001-2007年先后在德国马普分子生理研究所和美国亚利桑那州立大学从事博士后研究。
长期从事单分子生物物理方面的研究工作，提出新的红细胞膜结构模型（Semi-mosaic model）和有核组织细胞膜结构模型（Protein Layer-Lipid-Protein Island model）；设计开发了基于原子力显微镜的测量动态微观力系统（“力示踪”技术），实时记录了细胞膜转运单分子/单颗粒的过程；自主研发超分辨荧光成像和原子力显微镜的联用技术。在Chemical Society Reviews、Nature Communications、Nano Letters、Cell Research、JACS、PNAS等杂志发表论文90余篇，申请和授权发明专利11项。近五年共发表论文55篇（25篇IF>5，4篇IF>10），其中通讯联系人和第一作者论文43篇。论文总被引1600余次，其中2篇论文单篇引用分别为290和190余次。应邀担任国际期刊Scientific Reports的编委、中国化学会生物物理化学专业委员会委员、中国生物物理学会单分子生物学分会理事、国家自然基金委面上/青年/地区项目会评专家、科技部重点研发专项会评专家。
 
研究方向 Research direction
分析化学
生物物理
 
招生信息 Enrollment information 
专业背景：分析化学，细胞生物学，生物化学，物理学等；
考试科目：同中国科技大学招生考试
科研条件：课题组拥有AFM5500、AFM7500原子力显微镜各一台，适合在液相条件下对生物样品进行操作，同时也具备完善的显微操作系统和超分辨荧光显微镜。此外，课题组隶属于电分析化学国家重点实验室，可以利用的资源包括：Multimode Ⅷ原子力显微镜、Icon原子力显微镜、共聚焦荧光倒置显微镜、细胞培养室、流式细胞仪、PCR、FTIR、圆二色光谱仪、紫外-可见光谱仪、荧光光谱仪和常规实验设备。中科院长春应用化学研究所拥有电子显微镜和质谱等实验仪器可供使用。
学生待遇：同中国科学院长春应用化学研究所研究生待遇。
 
论文专著 The monograph
1) Mechanistic Insights into Membrane Protein Clustering Revealed by Visualizing EGFR Secretion - Research - 2022
2) The structure and function of cell membranes examined by atomic force microscopy and single-molecule force spectroscopy - Chemical Society Review - 2015
3) The process of wrapping virus revealed by a force tracing technique and simulations - Advanced Science - 2017
4) Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging - Proceedings of the National Academy of Sciences - 2018
5) Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters - Nanoscale Horizons - 2019
6) Assembly Characterization of Human Equilibrium Nucleoside Transporter 1 (hENT1) by Inhibitor Probe-Based dSTORM Imaging - Anal. Chem. - 2023
7) High glucose-induced glucagon resistance and membrane distribution of GCGR revealed by super-resolution imaging - iScience - 2023
8) Mechanistic Insights into Membrane Protein Clustering Revealed by Visualizing EGFR Secretion - Research - 2022
9) The structure and function of cell membranes examined by atomic force microscopy and single-molecule force spectroscopy - Chemical Society Review - 2015
10) The process of wrapping virus revealed by a force tracing technique and simulations - Advanced Science - 2017
11) Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging - Proceedings of the National Academy of Sciences - 2018
12) Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters - Nanoscale Horizons - 2019
13) High glucose-induced glucagon resistance and membrane distribution of GCGR revealed by super-resolution imaging - iScience - 2023
14) Assembly Characterization of Human Equilibrium Nucleoside Transporter 1 (hENT1) by Inhibitor Probe-Based dSTORM Imaging - Anal. Chem. - 2023
15) Mechanistic Insights into Membrane Protein Clustering Revealed by Visualizing EGFR Secretion - Research - 2022
16) The structure and function of cell membranes examined by atomic force microscopy and single-molecule force spectroscopy - Chemical Society Review - 2015
17) The process of wrapping virus revealed by a force tracing technique and simulations - Advanced Science - 2017
18) Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging - Proceedings of the National Academy of Sciences - 2018
19) Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters - Nanoscale Horizons - 2019
20) High glucose-induced glucagon resistance and membrane distribution of GCGR revealed by super-resolution imaging - iScience - 2023
21) Assembly Characterization of Human Equilibrium Nucleoside Transporter 1 (hENT1) by Inhibitor Probe-Based dSTORM Imaging - Anal. Chem. - 2023
 
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